The World Series and Mastercard to ‘Stand Up to Cancer’

Game three of the World Series will play a big part in standing up to cancer.

During the game, set to air on Halloween on FOX, a 30-second commercial spot for Mastercard's "Priceless" campaign will be a PSA for the charity Stand Up to Cancer. The spot will feature the live crowd at the game in Philadelphia, and will cut live to the ballpark at the end where "CBS Evening News" anchor Katie Couric (a founding member of Stand Up to Cancer) and actors Minka Kelly and Terrence Howard will encourage viewers to Stand Up to Cancer, as part of this year's World Series dedication to community service.

The PSA, produced by 'Spider-man' producer and cancer survivor Laura Ziskin, marks the first time that a Mastercard "Priceless" spot has been dedicated to a nonprofit.